中国超声内镜引导腹腔神经丛消融术专家共识（2025，上海）

Chinese expert consensus on the clinical practice of endoscopic ultrasound‑guided celiac plexus neurolysis (2025, Shanghai)

摘要:

有效的疼痛管理可显著提高终末期癌症患者的生活质量。尽管部分患者使用强阿片类药物后疼痛得到缓解，但仍有患者不能耐受其不良反应或需更多其他手段减轻疼痛，如超声内镜引导腹腔神经丛消融术（endoscopic ultrasound‑guided celiac plexus neurolysis，EUS‑CPN）。如何规范化和标准化进行EUS‑CPN的操作成为亟待解决的问题。随着EUS‑CPN及其衍生技术的不断进步，对于其临床优势、劣势和并发症的认识也在不断更新，国内外学者发表了大量的高质量研究以辅助决策并规范治疗流程。本共识在现有国内外相关指南的基础上，对近年来相关研究进展进行总结和更新，针对EUS‑CPN的临床指征、干预时机、技术选择、疗效、并发症等方面，以问答的形式提出了8个临床关注的问题和22条推荐意见，以期指导EUS‑CPN的规范化应用。

Abstract:

Effective pain control can significantly improve the quality of life of patients with end-stage cancer. Although some patients experience pain relief after using strong opioid drugs, there are still patients who cannot tolerate their adverse effects or need more other methods to relieve pain, such as endoscopic ultrasound-guided celiac plexus neurolysis (EUS-CPN). How to standardize and normalize the procedure of EUS-CPN has become an urgent matter. As EUS-CPN and its derivative technologies keep advancing, the understanding of clinical advantages, disadvantages, and complications of EUS‑CPN is also constantly updating. A large number of high-quality studies have been published by scholars at home and abroad to assist decision-making and standardization of the treatment procedure. This consensus, based on the existing domestic and international guidelines, summarized and updated the relevant research progress in recent years, and presented 8 clinical concerns and 22 recommendations in the form of questions and answers regarding clinical indications, intervention timing, technical selection, efficacy and complications, aiming to guide the standardized application of EUS-CPN.