胰岛素瘤内镜诊疗专家共识（2025年）

Expert consensus on endoscopic diagnosis and treatment for insulinoma (2025)

摘要:

胰岛素瘤是一种以胰岛素分泌过多导致低血糖为特征的罕见功能性胰腺神经内分泌肿瘤。内镜技术的进步为胰岛素瘤的诊断和治疗提供了重要的手段。早期诊断和有效干预（特别是内镜下干预）可显著改善患者生存期和生活质量。尽管国内外相关指南和共识提及胰岛素瘤，但针对性内镜诊疗仍缺乏具体、规范的实施标准以供参考。为此，中华医学会消化内镜学分会牵头组织，邀请国内相关领域的部分专家，结合国内外最新循证医学证据，依据推荐分级评估、制定和评价系统对内镜诊疗相关证据进行质量评估及推荐强度分级，制定《胰岛素瘤内镜诊疗专家共识（2025年）》。本共识聚焦于内镜引导下的诊断与治疗技术，旨在为胰岛素瘤的内镜规范化诊疗实践提供具体参考与操作指导，以期提升我国胰岛素瘤的内镜诊疗水平。

Abstract:

Insulinoma is a rare functional pancreatic neuroendocrine tumor characterized by excessive insulin secretion, which causes hypoglycemia. Advances in endoscopic technology have provided essential tools for the diagnosis and treatment of insulinoma. Early diagnosis and timely intervention, especially endoscopic intervention, can significantly improve survival and life quality of patients. Although insulinoma is mentioned in relevant domestic and international guidelines and consensus, there is still a lack of specific and normative implementation standards for the endoscopic diagnosis and treatment of insulinoma for reference. Therefore, Digestive Endoscopy Branch of Chinese Medical Association took the lead in organizing and inviting some experts in related fields in China to formulate Expert consensus on endoscopic diagnosis and treatment for insulinoma (2025). Based on the latest evidence-based medical evidence at home and abroad, and in accordance with the grading of recommendations assessment, development and evaluation (GRADE) system, the quality of the evidence related to endoscopic diagnosis and treatment was assessed and the strength of recommendations was classified. This consensus focuses on endoscopy-guided diagnostic and therapeutic approaches in order to provide specific references and practical guidance for standardized endoscopic diagnosis and treatment of insulinoma, and improve the quality of endoscopic diagnosis and treatment for insulinoma in China.