Abstract:Gastrointestinal endoscope reprocessing is a complex multi?step process, encompassing various stages from pre?cleaning to storage. Improper operation at any stage may lead to pathogens survival and infections. In recent years, outbreaks of gastrointestinal endoscope?related infections caused by multi?drug resistant bacteria occurred frequently, highlighting the importance of standardized reprocessing of gastrointestinal endoscopes. The consensus has reviewed and updated the reprocessing procedures for gastrointestinal endoscopy, referring to domestic and international literature, guidelines, and clinical practices, while also taking into the specific conditions in China. The consensus identifies 17 key clinical issues, including pre?cleaning, transportation, leak testing, manual cleaning, rinsing, disinfection/sterilization, drying, and storage, and provides 28 detailed operational recommendations for relevant professionals to ensure the effectiveness of gastrointestinal endoscope reprocessing.