Abstract:To investigate the therapeutic effects and safety of carotid sinus massage for the relief of hiccups during painless gastroscopy, patients with hiccups during elective painless gastroscopy in Beijing Friendship Hospital from May to June, 2024 were enrolled. According to the random number method, the patients were divided into 2 groups, including the experimental group and the control group. The patients with hiccups in the experimental group were treated with carotid sinus massage, and those in the control group were treated with abdominal compression. The improvement rate of hiccups, the gastroscopy success rate, the gastroscopy time, the image quality scores, the incidence of adverse reactions during and after gastroscopy, patient satisfaction, and endoscopist satisfaction of the two groups were mainly observed. Finally, 64 patients were included with 32 cases in the experimental group and 32 cases in the control group. There was no significant difference in baseline data between the two groups (P>0.05). The results showed that the improvement rate of hiccups in the experimental group was significantly higher than that in the control group [81.25% (26/32) VS 68.75% (22/32), χ2=5.741, P=0.017]. The gastroscopy time in the experimental group was significantly lower than that in the control group (11.63±1.66 min VS 15.25±1.68 min, t=-8.668, P<0.001). The gastroscopy success rate in the experimental group was significantly higher than that in the control group [90.62% (29/32) VS 68.75% (22/32), χ2=4.730, P=0.030]. The image quality score in the experimental group was significantly higher than that in the control group (37.97±1.15 scores VS 36.59±1.54 scores, t=4.044, P<0.001). The endoscopist satisfaction in the experimental group was higher than that in the control group [93.75% (30/32) VS 62.50% (20/32), χ2=9.143, P=0.002]. There was no significant difference in the incidence of adverse reactions during and after gastroscopy or patient satisfaction between the two groups (P>0.05).The primary outcomes indicate that carotid sinus massage is an effective and safe treatment for relief of hiccups during painless endoscopy. At the same time, this treatment helps endoscopists to perform endoscopy continuously, which increases the gastroscopy success rate and shortens the examination time.