胆囊息肉对结直肠息肉提示价值的相关性研究

Correlation between gallbladder polyps and colorectal polyps

摘要:

目的 探讨胆囊息肉与结直肠息肉的关系，为胆囊息肉是否可以作为行结肠镜检查的提示提供依据和线索。方法 回顾性收集石河子大学第一附属医院2022年1-12月2 542例行结肠镜检查及腹部超声的患者临床病历，按照患者结肠镜检查结果将所有纳入患者分为结直肠息肉组（n=1 266）和无结直肠息肉组（n=1 276）。采用单因素及多因素二元Logistic回归模型分析胆囊息肉与结直肠息肉的关系。结果 结直肠息肉组及无结直肠息肉组的胆囊息肉患病率分别为16.67%（211/1 266）和11.21%（143/1 276）。多因素Logistic回归分析显示女性患结直肠息肉风险较低（P<0.001，OR=0.523，95%CI：0.440~0.622），年龄（P<0.001，OR=1.059，95%CI：1.050~1.068）、高甘油三酯血症（P=0.013，OR=1.350，95%CI：1.066~1.709）、高密度脂蛋白降低（P<0.001，OR=1.588，95%CI：1.280~1.969）和胆囊息肉（P<0.001，OR=1.712，95%CI：1.344~2.180）是结直肠息肉的独立危险因素。结直肠息肉组与无结直肠息肉组相比，在高胆固醇血症、低密度脂蛋白升高、高尿酸血症以及胆囊切除之间差异无统计学意义（P>0.05）。结论 腹部超声发现胆囊息肉提示患者患有结直肠息肉可能，建议存在胆囊息肉的患者有必要进一步行结肠镜筛查以提高结直肠息肉检出率。

Abstract:

Objective To explore the relationship between gallbladder polyps and colorectal polyps, providing insights into whether the presence of gallbladder polyps can serve as an indicator for colonoscopy screening. Methods Clinical data from 2 542 patients who underwent colonoscopy and abdominal ultrasound at the First Affiliated Hospital of Shihezi University between January and December 2022 were retrospectively analyzed. Patients were divided into colorectal polyp group (n=1 266) and non-colorectal polyp group (n=1 276) based on colonoscopy findings. Univariate and multivariate Logistic regression models were used to analyze the relationship between gallbladder polyps and colorectal polyps. Results The prevalence rates of gallbladder polyp in colorectal polyp group and non-colorectal polyp group were 16.67% (211/1 266) and 11.21% (143/1 276). Multivariate Logistic regression analysis showed a lower risk of colorectal polyps in women (P<0.001, OR=0.523, 95%CI: 0.440-0.622). Age (P<0.001, OR=1.059, 95%CI: 1.050-1.068), and hypertriglyceridemia (P=0.013, OR=1.350, 95%CI: 1.066-1.709), low level of high-density lipoprotein (P<0.001, OR=1.588, 95%CI: 1.280-1.969), and gallbladder polyp (P<0.001, OR=1.712, 95%CI: 1.344-2.180) were independent risk factors for colorectal polyp. There was no significant difference in hypercholesterolemia, elevated low-density lipoprotein, hyperuricemia, or cholecystectomy between colorectal polyp group and non-colorectal polyp group (P>0.05). Conclusion The identification of gallbladder polyps via abdominal ultrasound may indicate a higher likelihood of colorectal polyps in patients, underscoring the need for further colonoscopy screening in individuals with gallbladder polyps.