Abstract:Endoscopy-guided endobiliary radiofrequency ablation has been an emerging treatment for malignant biliary strictures in recent years. It can effectively delay the local progression of tumors, improve the quality of life, and prolong the survival of patients, combined with biliary stenting and systemic chemotherapy, etc, which is mainly suitable for inoperable patients with extrahepatic cholangiocarcinoma and ampullary cancer. Based on the existing clinical evidence, Digestive Endoscopology Branch of Chinese Medical Association, Digestive Endoscopy Professional Committee, Endoscopic Physicians Branch of Chinese Medical Doctor Association, and National Clinical Research Center for Digestive Diseases (Shanghai) organized relevant experts to discuss the indications, contraindications, technical operation specifications and complications prevention and treatment of endoscopic guided endobiliary radiofrequency ablation, and to reach consensus statements, providing references for the clinical standardized treatment for biliary malignant tumors.