Abstract:Objective To evaluate the effectiveness of oral-nasal oxygen supply mouth guard in painless gastroscopy for snoring patients. Methods The snoring patients who underwent painless gastroscopy at two Endoscopy Centers of Shanghai East Hospital, Tongji University in July 2022 were randomly divided into the observation group (using oral-nasal oxygen supply mouth guard) and the control group (using ordinary nasal oxygen tube and mouth guard). Parameters such as the wearing time and the removal time of the mouth guard, lowest pulse oxygen saturation (SpO2), incidence of hypoxemia, and the satisfaction of medical staff were compared between the two groups. Results The wearing time of mouth guard was 11.63±0.84 seconds and the removal time was 5.33±0.76 seconds in the observation group (n=40), which were lower than those in the control group (n=47) (14.91±1.21 seconds, t=-14.463, P<0.001; 10.38±0.80 seconds, t=-30.095, P<0.001). The wearing satisfaction score was 9.80±0.61, the lowest SpO2 was (96.70±3.42)%, the removal satisfaction score was 9.75±0.67, and the anesthesiologists'' satisfaction score was 9.20±1.42 in the observation group, which were higher than those in the control group [7.70±0.93, t=12.209, P<0.001; (94.06±3.72)%, t=3.417, P=0.001; 7.96±0.98, t=9.803, P<0.001; 8.13±1.35, t=3.615, P=0.001] with significant difference. There was no significant difference in the incidence of hypoxemia [10.00% (4/40) VS 14.89% (7/47), χ2=0.130, P=0.718] and endoscopic physician satisfaction score (9.30±0.97 VS 9.02±1.31, t=1.112, P=0.269) between the two groups. Conclusion The oral-nasal oxygen supply mouth guard is easy to wear and remove, effectively reducing SpO2 fluctuations during painless gastroscopy for snoring patients. It can enhance medical staff satisfaction with high clinical value.