内镜下光动力治疗胰腺导管内乳头状黏液性肿瘤2例

Endoscopic photodynamic therapy for pancreatic intraductal papillary mucinous neoplasm:two cases report

摘要:

胰腺导管内乳头状黏液性肿瘤是一种以导管扩张、导管内乳头状生长和黏液分泌为特征的肿瘤，具有一定的恶变潜能。内镜下光动力治疗是一种腔内局部治疗肿瘤的新技术，可使肿瘤组织坏死、脱落，达到局部杀灭肿瘤的作用。本文报道了2例内镜下光动力治疗该病的病例，总体疗效满意。

Abstract:

Objective To explore the clinical efficacy of endoscopic photodynamic therapy (PDT) in intraductal papillary mucinous neoplasm of the pancreas. Methods Data of 2 patients with IPMN of pancreas were collected in Shandong Provincial Third Hospital from July 2020 to August 2020. Low-grade papillary mucinous adenoma of the pancreas were all pathologically confirmed before surgery. Hematoporphyrin was injected intravenously 48 hours before surgery. The first endoscopic PDT was performed and the second PDT irradiation was performed 24 hours after the operation. Then we evaluate the success rate and complications of the PDT, and the clinical efficacy was also evaluated 18 months after PDT. Results Endoscopic PDT treatments were all successfully completed in 2 patients with a technical success rate of 100%. Case 1 received a total of 3 PDT treatments, and case 2 received a total of 1 PDT treatment. No complications such as acute cholangitis, acute pancreatitis, pancreatic leakage and pancreatic duct stricture occurred. No recurrence of adenoma was found in CT or MRCP at 18 months after operation. Conclusion Endoscopic PDT for IPMN of the pancreas is safe and effective, while it needs a large sample, multi-center clinical research to confirm its long-term efficacy.