“雪碧零卡®”在磁控胶囊内镜胃准备方案中的应用初探

Gastric preparation with Sprite Zero® for magnetically controlled capsule endoscopy

摘要:

目的 探究400 mL雪碧零卡®作为磁控胶囊内镜（magnetically controlled capsule endoscopy，MCE）检查胃准备方案的可行性。方法 本随机对照研究于2019-12-16至2020-01-15在海军军医大学长海医院消化内科开展。拟行胶囊内镜的患者及健康志愿者按1∶1的比例被随机分为雪碧（S）组和纯水（W）组。W组受试者在吞咽胶囊前10 min饮用纯水800 mL，而S组受试者则用400 mL“雪碧零卡®”饮料代替纯水。本研究主要研究终点为胃充盈度评分，次要终点包括饱胀感评分、胃通过时间（gastric transit time，GTT）、小肠通过时间（small bowel transit time，SBTT）、小肠检查完成率以及诊断效能。结果 共102例受试者纳入分析（S组52例，W组50例）。S组受试者中位液体摄入量明显少于W组（500 mL比950 mL，P<0.001）的情况下，两组在吞服胶囊0~5 min、>5~10 min、>10~15 min时胃充盈中位评分均能稳定在4.0分（P>0.05）。S组饱腹感较W组显著缓解（7.0分比7.5分，P=0.030），GTT<30 min受试者占比较W组显著增加［69.57%（16/52）比27.59%（8/29），P=0.030］，且S组的小肠检查完成率达到了100.00%，高于W组的89.66%（P=0.245）。结论 400 mL雪碧与800 mL水相比，不仅能够充分充盈胃腔，而且具有较优的舒适性，加速胃排空，间接提高了小肠检查的完成率，作为胃准备方案具有良好可行性。

Abstract:

Objective To explore the feasibility of 400 mL Sprite Zero® in gastric preparation for magnetically controlled capsule endoscopy (MCE) . Methods A randomized controlled trial at the Department of Gastroenterology of Changhai Hospital, Naval Medical University from December 16th, 2019 to January 15th, 2020 was conducted. The patients and healthy volunteers who intended to receive MCE were randomly divided into the Sprite Zero® (S) group and the water (W) group at 1∶1. For subjects in the W group, 800 mL water was taken 10 minutes before swallowing the capsule. And for subjects in the S group, 400 mL Sprite Zero® was taken. The primary endpoint was gastric filling score and the secondary endpoint included the fullness score, gastric transit time (GTT), small bowel transit time (SBTT), completion rate (CR) for small bowel examination and the diagnostic yield. Results A total of 102 subjects were enrolled, 52 subjects in the S group and 50 subjects in the W group. The median score of gastric filling was 4 at 0-5 min, >5-10 min and >10-15 min after taking the capsule in both groups, with less median liquid consumption in the S group than the W group (500 mL VS 950 mL, P<0.001). The S group showed lower median fullness score (7.0 scores VS 7.5 scores, P=0.030) and higher proportion of patients with GTT less than 30 minutes [69.57% (16/52) VS 27.59% (8/29), P=0.030] compared with the W group. The CR of small bowel examination in the S group was 100.00%, higher than that of the W group (89.66%, P=0.245). Conclusion Compared with 800 mL water, 400 mL Sprite Zero® can fully fill the stomach with more comfort. It has the potential to accelerate gastric emptying and improve the CR of small bowel examination, which is feasible for the gastric preparation.