Abstract:Objective To compare the efficacy and safety in the treatment of early gastric cancer between ESD and surgery. Method Collect clinical data of patients who undertook ESD and surgery in Beijing Friendship hospital from June 2012 to May 2018, compare the complete resection rate, complication rate, hospital duration and expense between two groups. Result There is no significant difference between two groups in complete resection rate(95.7% VS 98.9%,P=1.191), neither in the complication rate(5.9% VS 8.2%,P=0.471). There is significant difference in the hospital duration(11.5±3.7 VS 19.4±13.0,P<0.05) , and in hospital expense (27383.1±10143.0 VS 78004.3±79027.8,P<0.05). Conclusions: ESD is comparable to surgery in efficacy and safety in the treatment of early gastric cancer, ESD is superior than surgery in the hospital duration and expense.